PARATUBERCULOSIS

Paratuberculosis is a disease that generates great economic losses and big health concerns. It is caused by bacteria of Mycobacterium avium subsp. paratuberculosis and it is endemic throughout the world affecting both meat and milk industry.


Diagnosis of subclinical infection is very difficult an therefore, vaccination remains as a key tool for effective control of Paratuberculosis.

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PHARMAECONOMY

OUR VACCINES

AWARENESS

AFFECTED SPECIES

Sheep

Sheep

Goats

Goats

Cattle

Cattle

CONTAMINATION

Mycobacterium avium subsp.
paratuberculosis
is able to survive in
the environment for relatively long
periods

11 months
in soil contaminated
with faeces
Between
5 and 9
months

in water
17 months
in laboratory conditions

TRANSMISSION

Oral transmission

Oral transmission.

Contaminated Food, soil, water,
milk and colostrum.

Transplacental transmission

Transplacental transmission.

In almost 40% of cows with
subclinical disease.

RISK FACTORS

Replacement of animals from herds with unknown paratuberculosis status

Contact of own Young replacers with adult animal faeces

Water and food contamination

Contamination of calves by faeces in udders

Poor equipement hygiene

CLINICAL SIGNS

  1. Diarrhoea and progressive weight loss

  2. General weakness

  3. Decrease of production

STAGES OF DISEASE

Stage 1

Silent infection

No clinical signs. No
transmission
10-14 animals

Stage 2

Subclinical disease

No clinical signs.
transmission
4-8 animals

Stage 3

Clinical disease

No clinical signs and
transmission
1-2 animals

Stage 4

Terminal disease

Advanced disease
1 animal

1 animal in stage 4,
indicates 24 animals with the
proliferation of the disease

ECONOMIC LOSSES

Death
of animals
US $200 - $900
of losses per cow
30 to 54kg
decrease of meat production
700 liters
per cow decrease of milk production
30%
reduction

of market value per animal
50% decrease
of productive life

HOW TO CONTROL AND PREVENT

BIOSAFETY

EDUCATION

VACCINATION

DIAGNOSIC METHODS

Reducing contamination by adequate sanitary control. Wash and disinfect the equipment

Of farmers

Reduce risks of microbial contamination and production losses

PCR or Elisa and bacterial culture

OUR VACCINES

GUDAIR

Gudair is the only existing
vaccine worldwide for the
immunization of Mycobacterium
avium
ssp. paratuberculosis in
sheep and goats

GUDAIR

SILIRUM

Silirum is an inactivated vaccine
for the immunization of
Mycobacterium avium ssp.
paratuberculosis in cattle

SILIRUM

GUDAIR

Gudair is the only existing
vaccine worldwide for the
immunization of Mycobacterium
avium
ssp. paratuberculosis in
sheep and goats

GUDAIR

SILIRUM

Silirum is an inactivated vaccine
for the immunization of
Mycobacterium avium ssp.
paratuberculosis in cattle

SILIRUM

We talked with the expert in paratuberculosis
Dr. Ramón A. Juste, president of the
International Association of Paratuberculosis